Mass Spectrometry Facility Core Services

The Mass Spectrometry Facility (MSF) in the Department of Chemistry provides staff services and walk-up access to a variety of mass spectrometry instruments suitable for the analysis of small molecules, peptides/proteins and nucleic acids. The MSF provides services principally to faculty research groups in Chemistry and other UC departments/schools, but also accepts samples from outside academic/non-profit and commerical clients.

	Training	Resources: Forms, Calendars

The MSF operates 20 instruments that are equipped with liquid chromatography (LC), gas chromatography (GC) or matrix assisted laser desorption (MALDI) input sources coupled to quadrupole or time-of-flight (TOF) MS systems. All instruments have extensive sets of pre-programmed methods availble that are suitable for the majority of samples typically encountered; method customization can also be accommodated.

facilityInstruments include: Waters G2-XS QTOF, Waters Synapt G2 (x2), Waters QTOF-2, Waters Q-TOF Premier, Waters LCT Premier (x2), Waters LCT Classic (x2), Waters GCT, Agilent 610 LC-MS TOF, Shimadzu IT-TOF, Thermo LTQ-XL Orbitrap, Thermo TriPlus Ultra GC-MS (liquid/headspace, SPME), Thermo GC-MS/FID, Agilent GC-MS/FID w/ TD (volatiles), Agilent GC-FID/TCD (gases), AB Sciex 5800 MALDI-TOF, Bruker ultrafleXtreme (imaging mass spectrometry), Metrohm 940 Vario IC Pro (ion chromatography),and various Agilent/Waters/Beckman HPLC systems.

MSF staff provide regular weekly user/instrument training sessions, project consultation, assistance with method development, advanced MS services and data analyses. Qualified trained users may access the facility and instruments 24/7 and are encouraged to run their own samples. Consequently, users can often obtain results wihtin minutes. Core staff services include: accurate mass molecular formula validation, exact mass measurements of intact peptide/protein/oligonucleotides, peptide sequencing, post-translational modifications (PTMs), targeted and untargeted metabolomics including triplequad quantitation, and imaging mass spectrometry applications.

For more information on services and training, contact Felix Grün, PhD (Facility Director)