MALDI Matrices

Common MALDI matrices and their uses.

Matrix	Mode	Proteins	Peptides	Lipids	Metabolites	Saccharides	Other
a-Cyano-4-hydroxycinnaminic acid (CHCA)	P	Y	Y	Y		N-glycans
2,5-Dihydroxybenzoic acid (DHB)	P/N	Y	Y	Y			Drugs
Super DHB	P/N	Y	Y			Y
Sinnapinic acid (SA)	P	Y
1,5-Diaminonaphthalene (DAN)	P/N			Y	Y
9-Aminoacridine (9-AA)	N	Y		Y
2,5-Dihydroxyacetophenone (2,5-DHA)	P/N		Y	Y			Acidic compounds
Norharmane (NRM)	P/N, Ionic liquid			Y	Y		Bile Acids, cardiolipins, endotoxin lipid A
N1,N4-diphenzylidenebenzene-1,4-diamine (DBDA)	N			FFAs	AAs		Nucleotides
3,4-Dimethoxycinnamic acid	P			Y
2,5- Dihydroxyacetophenone	N					Y
Quercetin	P			Y
3-Aminophthalhydrazide	P/N			Glycero(P)lipids, sphingolipids		Saccharolipids	Nucleotides
Nifedipine	N						Polyphenols
Hydralazine	P/N			Y			FFAs, phosphatidylinositols, sulfatides
2,3, Dicyanohydroquinone	P			Y
N-Phenyl-2-naphthylamine	N		Y	FFAs,	AAs		Antioxidants
1,6-Diphenyl-1,3,5-hexatriene	N			FFAs
Basic Blue 7	P/N			Y